Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5.
The stalling of RNA polymerase II (RNAPII) at the promoters of many genes, including developmental regulators, stress-responsive genes, and HIVLTR, suggests transcription elongation as a critical regulatory step in addition to initiation.Spt5, the large DEODORANT STICK CITRUS VETIVER subunit of the DRB sensitivity-inducing factor (DSIF), represses